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i think it would get the same mileage as the standard 4x4 5.4. it's an offroad truck, but i watched Bullrun rally and the dude that was driving a Raptor said it handles great on the highway, being an offroad truck.
Like Ryan says the ride height will def play a part as well as the rear end ratio and tires. Your prob looking at 1-2mpg less in normal driveing. I guess the extra width will also play a part in worse aerodynamics.